PSIP1 (PC4 and SFRS1 interacting protein 1)
نویسندگان
چکیده
منابع مشابه
Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer
Women with epithelial ovarian cancer (EOC) are usually treated with platinum/taxane therapy after cytoreductive surgery but there is considerable inter-individual variation in response. To identify germline single-nucleotide polymorphisms (SNPs) that contribute to variations in individual responses to chemotherapy, we carried out a multi-phase genome-wide association study (GWAS) in 1,244 women...
متن کاملPsip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins
Trithorax and polycomb group proteins are generally thought to antagonize one another. The trithorax family member MLL (myeloid/lymphoid or mixed-lineage leukemia) is presumed to activate Hox expression, counteracting polycomb-mediated repression. PC4 and SF2 interacting protein 1 (PSIP1)/p75, also known as LEDGF, whose PWWP domain binds to H3K36me3, interacts with MLL and tethers MLL fusion pr...
متن کاملProteomic analysis of H 3 K 36 me 3 and PSIP 1 / p 75 ( LEDGF ) complexes reveal their wider role in DNA repair
Trimethylation at histone H3 at lysine 36 (H3K36me3) is Background: associated with expressed gene bodies and recruit proteins implicated in transcription, splicing and DNA repair. PC4 and SF2 interacting protein ( ) is a transcriptional coactivator, possesses a H3K36me3 reader PSIP1/LEDGF PWWP domain. Alternatively spliced isoforms of PSIP1 binds to H3K36me3 and suggested to function as adapt...
متن کاملProteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF)
Trimethylation at histone H3 at lysine 36 (H3K36me3) is Background: associated with expressed gene bodies and recruit proteins implicated in transcription, splicing and DNA repair. PC4 and SF2 interacting protein ( ) is a transcriptional coactivator, possesses a H3K36me3 reader PSIP1/LEDGF PWWP domain. Alternatively spliced isoforms of PSIP1 binds to H3K36me3 and suggested to function as adapt...
متن کاملA Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
Lens epithelium derived growth factor (LEDGF), also known as PC4 and SFRS1 interacting protein 1 (PSIP1) and transcriptional co-activator p75, is the cellular binding partner of lentiviral integrase (IN) proteins. LEDGF accounts for the characteristic propensity of Lentivirus to integrate within active transcription units and is required for efficient viral replication. We now present a crystal...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38451